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The leucine metabolite, β-hydroxy-β-methylbutyrate (HMB), is a nutritional supplement that increases lean muscle and strength with exercise and in disease states. HMB is presently available as the Ca salt (CaHMB). The present study was designed to examine whether HMB in free acid gel form will improve HMB availability to tissues. Two studies were conducted and in each study four males and four females were given three treatments in a randomised, cross-over design. Treatments were CaHMB (gelatin capsule, 1 g), equivalent HMB free acid gel swallowed (FASW) and free acid gel held sublingual for 15 s then swallowed (FASL). Plasma HMB was measured for 3 h following treatment in study 1 and 24 h with urine collection in study 2. In both the studies, the times to peak plasma HMB were 128 (sem 11), 38 (sem 4) and 38 (sem 1) min (P
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MyHMB Clear is the pure, free acid form of HMB. This powerful delivery form is rapidly absorbed, allowing for a higher peak and greater concentration in the blood for maximum results. Additionally, myHMB Clear has greater clearance and utilization by your tissues to maximize benefits.
The leucine metabolite, β-hydroxy-β-methylbutyrate (HMB), is a nutritional supplement that increases lean muscle and strength with exercise and in disease states. HMB is presently available as the Ca salt (CaHMB). The present study was designed to examine whether HMB in free acid gel form will improve HMB availability to tissues. Two studies were conducted and in each study four males and four females were given three treatments in a randomised, cross-over design. Treatments were CaHMB (gelatin capsule, 1 g), equivalent HMB free acid gel swallowed (FASW) and free acid gel held sublingual for 15 s then swallowed (FASL). Plasma HMB was measured for 3 h following treatment in study 1 and 24 h with urine collection in study 2. In both the studies, the times to peak plasma HMB were 128 (sem 11), 38 (sem 4) and 38 (sem 1) min (P
Effect of beta-hydroxy-beta-methylbutyrate free acid (HMB-FA) supplementation on serum creatine kinase (CK), cortisol, and perceived recovery score (PRS) in participants performing a 12-week resistance-training regimen
Effect of beta-hydroxy-beta-methylbutyrate free acid (HMB-FA) supplementation on serum creatine kinase (CK), urinary 3-methylhistidine:creatinine ratio (3MH:Cr), cortisol, and perceived recovery score (PRS) in participants during the overreaching phase, weeks 8, 9, and 10, of a 12-week resistance-training regimen
It's been a popular supplement for most of the last decade for these reasons, but for most of that time, there was only one type of HMB: HMB-Ca, which came in the form of a calcium salt. In recent years, a new version, HMB-FA or "free acid" has been promising even greater results.
HMB is a metabolite of the amino acid leucine, meaning that when we eat protein, a small percentage gets converted to HMB. However, you would need to consume 60 grams of leucine, or up to 750 grams of high-quality protein per day, to obtain an effective dose of HMB (3 grams per day) through your diet. Therefore, taking a supplemental form of HMB is ideal.
Recently, HMB free acid (HMB-FA) has been publicized as the superior form of HMB. Here's the reasoning: HMB-Ca generally has a slow rate of appearance in the bloodstream after ingestion, taking approximately 60-120 minutes to reach peak concentrations in the blood.[5]
On the other hand, when HMB is provided in its free acid form, the absorption rate is accelerated, resulting in peak HMB concentrations in the bloodstream approximately 30 minutes after ingestion.[5, 6, 7] Not only does HMB-FA appear more rapidly in the bloodstream compared to HMB-Ca, it also yields greater peak HMB concentrations. Lastly, an increased clearance rate was also observed with HMB-FA, presumably as a result of better uptake by the muscle.[8]
First and foremost, very few studies have directly compared the effects of HMB free acid versus HMB-Ca, making it difficult to determine if HMB-FA is truly a superior form of HMB. A recent study investigating the impact of HMB-Ca on muscle metabolism concluded that, despite the proposed differences in bioavailability, HMB-Ca provides a comparable anabolic and anti-catabolic effect compared to HMB-FA.[10]
When combined with resistance training, HMB free acid supplementation may lessen markers of muscle damage, augment immune and hormone responses, and enhance training-induced muscle mass and strength. HMB-FA supplementation may also improve markers of aerobic fitness when combined with HIIT training. Those are all compelling reasons to try it.
To date, the majority of researchers utilized supplementation of commercially available calcium salt form of HMB (HMB-Ca) [7,11,12,13] and research studies in this area reported conflicting results when supplemented with HMB-Ca during a resistance training intervention. However, a new free form of HMB (HMB-FA) has been shown to have a more rapid and higher bioavailability compared to HMB-Ca [14,15]. Fuller et al. [14] found that HMB-FA had a 25% greater clearance in the body and faster absorption when compared to HMB-Ca (36 vs. 131 min). These data suggest that acute supplementation with HMB-FA may be more effective than HMB-Ca for reducing muscle damage [16,17,18], inflammatory response [15,16] and anabolic hormones induction [10]. However, to our knowledge, only one study examined the effect of chronic supplementation of HMB-FA on strength and power adaptations following resistance training. Wilson et al. [8] investigated the effects of 12 weeks of HMB-FA supplementation on muscle mass, strength and power in resistance-trained men and found that HMB-FA induced greater gains in comparison to the placebo group. In addition, the creatine phosphokinase and cortisol responses to resistance training were lower for HMB-FA. The greater absorption rate and bioavailability of HMB-FA may provide greater benefits regarding its efficacy as a nutrient supplement used to enhance training adaptations [14,18], thus shortening the length of time needed between supplementation and exercise. This may potentially allow the athlete a shorter recovery time and an increase in performance in subsequent training session.
With review of hormonal changes (Table 2), these results suggest that HMB-FA may affect growth hormone/ insulin like growth factor 1 (GH/IGF-1) axis signaling; however, the effect on skeletal muscle protein synthesis requires more investigation. It is possible that the GH/IGF-1 axis signaling could require a large change in plasma HMB (i.e., HMB-FA) levels and it appears that chronic supplementation with free acid HMB form induced meaningful effects on GH/IGF-1 axis (very large to large training effects, Table 2) resulting in body mass increase and strength gain [27].
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Clear Muscle is packed with BetaTOR, a unique metabolite and free-acid HMB derivative of leucine - the most powerful amino acid. By building on the recovery benefits of traditional amino acids, this supplement leads to better performance, strength, endurance and lean muscle growth. One clinical study on BetaTOR showed that subjects increased protein synthesis by more than 70% and reduced muscle breakdown by 58% at the same time. Clear Muscle is proudly engineered to unlock your abilities, exceed your potential, achieve maximum performance and reach peak power.
In a comprehensive review of HMB studies over the past two decades, the authors examine HMB efficacy. This review also examines why many newer studies, longer in length than some of the original studies and also conducted with HMB in the free acid form, are suggestive of stronger efficacy in both trained and untrained populations. The authors concluded that recent studies utilizing high-intensity training have demonstrated HMB efficacy in maintaining muscle mass and attenuating the inflammatory response. In particular these studies show improved efficacy of HMB free acid in trained athletes.
Elite infantry soldiers were supplemented with either HMB free acid (BetaTOR) or a placebo and underwent an advanced military training, which consisted of periods of restricted sleep and severe environmental stressors. Over the 23-day study the researchers saw a decrease in the insulin growth factor binding protein number 7 (IGFBP-7). The reduction in this protein indicated a reduced stress response, and warrants further investigation into the physiological role of HMB free acid (BetaTOR) in reducing stress during intense military training protocols.
Healthy men supplemented with HMB free acid (BetaTOR) (3 g/d) and underwent a six week resistance training program. BetaTOR supplementation improved the anabolic adaptations (GH/IGF-1) and decreased catabolic stress hormones (cortisol/ACTH). Similar to previous studies BetaTOR supplementation also improved strength and power during the training when compared to placebo-supplemented men.
This paper reviews the first nine studies conducted in humans with HMB free acid through 2016. The studies involved resistance training protocols and high intensity interval training (HIIT). HMB free acid was shown in all of the studies to improve outcomes by improving recovery, improving performance (aerobic metabolism and strength), increasing lean muscle mass and decreasing fat mass, and improving immune and endocrine response to intense exercise. These studies demonstrate the utility of HMB free acid as an ergogenic aid for muscle over a variety of exercise regimens. 041b061a72